For the second straight game, the 49ers pounded the ball on the ground and for the second straight game they made sure to get the ball in the hands of Deebo Samuel. The Saints entered the game with the No. 1 run defense and were No. 1 in yards per carry allowed and the Eagles torched them for 242 yards and 4.8 yards per carry on 50 attempts. For the second straight game, the defense stood tall as well, and forced the Panthers to turn the ball over on downs on their final two drives of the game. Pittsburgh received a solid game from Ben Roethlisberger, who has nine touchdowns and no interceptions over his last five games.